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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHX8 All Species: 14.85
Human Site: T329 Identified Species: 27.22
UniProt: Q14562 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14562 NP_004932.1 1220 139315 T329 K V L S F T G T K T S L S M K
Chimpanzee Pan troglodytes Q7YR39 1044 119631 K240 S R R E Y L A K R E R E K L E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537627 1216 138553 T325 K V L S F T G T K T S L S M K
Cat Felis silvestris
Mouse Mus musculus A2A4P0 1244 142553 T353 K V L S F T G T K T S L S M K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418105 1076 123154 L272 G L V H I S E L R R E G R V A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002663993 1210 138002 S319 K V L S F T G S K T S L S M K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610928 1242 141917 Q349 K V M S I T G Q K V S L S M K
Honey Bee Apis mellifera XP_623289 1192 136394 Q303 K V L N I G G Q K V S L S M K
Nematode Worm Caenorhab. elegans Q09530 1200 135741 G297 K V N K I E N G K I S L S M K
Sea Urchin Strong. purpuratus O17438 455 51461
Poplar Tree Populus trichocarpa XP_002318357 1207 137837 N315 K V I S I L G N K L S L S M R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38953 1168 134139 S281 S S D K Y S L S M R D V D Q N
Baker's Yeast Sacchar. cerevisiae P24384 1145 129992 P294 K R R A L T S P E R W E I R Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40 N.A. 98.5 N.A. 96.8 N.A. N.A. N.A. 84 N.A. 91.1 N.A. 69.4 71.8 61.3 21.9
Protein Similarity: 100 59 N.A. 99.1 N.A. 97.3 N.A. N.A. N.A. 86.8 N.A. 94.5 N.A. 82 83.9 75.4 28.8
P-Site Identity: 100 0 N.A. 100 N.A. 100 N.A. N.A. N.A. 0 N.A. 93.3 N.A. 73.3 66.6 53.3 0
P-Site Similarity: 100 26.6 N.A. 100 N.A. 100 N.A. N.A. N.A. 33.3 N.A. 100 N.A. 80 73.3 53.3 0
Percent
Protein Identity: 59.1 N.A. N.A. 59.3 44.2 N.A.
Protein Similarity: 75 N.A. N.A. 75.4 62.8 N.A.
P-Site Identity: 60 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 73.3 N.A. N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 0 0 8 0 8 0 0 % D
% Glu: 0 0 0 8 0 8 8 0 8 8 8 16 0 0 8 % E
% Phe: 0 0 0 0 31 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 8 54 8 0 0 0 8 0 0 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 39 0 0 0 0 8 0 0 8 0 0 % I
% Lys: 70 0 0 16 0 0 0 8 62 0 0 0 8 0 54 % K
% Leu: 0 8 39 0 8 16 8 8 0 8 0 62 0 8 0 % L
% Met: 0 0 8 0 0 0 0 0 8 0 0 0 0 62 0 % M
% Asn: 0 0 8 8 0 0 8 8 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 16 0 0 0 0 0 8 8 % Q
% Arg: 0 16 16 0 0 0 0 0 16 24 8 0 8 8 8 % R
% Ser: 16 8 0 47 0 16 8 16 0 0 62 0 62 0 0 % S
% Thr: 0 0 0 0 0 47 0 24 0 31 0 0 0 0 0 % T
% Val: 0 62 8 0 0 0 0 0 0 16 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _